The application of phosphatidylserine has been recognized by the country and the enzyme modification method is the mainstream production process.

Phosphatidylserine (Phosphatidylserine), abbreviated as PS, also known as compound nervonic acid and diacylglycerol phosphoserine, is a natural phospholipid found in the biofilms of animals, higher plants and microorganisms. Phosphatidylserine can be used in drug delivery systems, dietary supplements, cosmetic surfactants and other fields.

Phosphatidylserine is the only phospholipid that can regulate the functional status of key cell membrane proteins and is an indispensable substance for the human body. Relevant studies have shown that phosphatidylserine has the functions of regulating blood lipids, improving memory, protecting the liver, strengthening the brain and delaying aging. It is the best health food for preventing and treating Alzheimer’s disease in the elderly. It has been used by South Korea, the United States, Japan, and China It has been recognized by the Food and Drug Administration of other countries and has been used in food, beverages, health products and other products.

There are three production processes for phosphatidylserine: chemical synthesis, extraction and purification from animal brain or soybean phospholipids, and biological enzyme conversion. Among them, the phosphatidylserine produced by chemical synthesis has many isomers, and the purification process is complicated; the production of phosphatidylserine from animal brains has the risk of disease transmission, and the production of soybean phospholipids as raw materials has the problem of low phosphatidylserine content and separation. Due to its high cost and difficulty in purification, chemical synthesis and extraction and purification methods have not been commercially applied. At present, more and more phosphatidylserine products are prepared through enzyme modification methods. Phospholipase D can catalyze the phosphate bond at the C-3 head end of glycerol, and catalyze the combination of phosphatidyl residues with serine under certain conditions. Generates a single phospholipid product called phosphatidylserine. Phosphatidylserine obtained through enzymatic modification has the characteristics of mild reaction conditions, fast speed, few by-products, and accurate enzyme action site.

In recent years, with the increasing market recognition of phosphatidylserine and the advancement of phosphatidylserine process technology, the number of companies entering the phosphatidylserine industry has increased, but the scale of the companies is generally small. At the same time, since phosphatidylserine is used in food and drugs, its quality and safety is very important. In 2023, the country issued “Phosphatidylserine” (standard number QB/T 5821-2023) to guide the healthy development of the industry . According to the released “China Phosphatidyl Serine Industry Market In-depth Research and Development Prospects Forecast Report 2023-2028”, China’s Phosphatidyl Serine Industry The main serine production companies include Shandong Bianrui Biopharmaceutical Co., Ltd., Wengyuan Guangye Qingyi Food Technology Co., Ltd., Inner Mongolia Jindawei Pharmaceutical Co., Ltd., Chengdu Xiankang Biotechnology Co., Ltd., and Lixing (Tianjin) Biotechnology Co., Ltd. wait.

Industrial analysts said that driven by industry standards and against the background of increasing people’s health awareness, the phosphatidylserine industry will gain further development.