Dexterobornol has extremely high medicinal value and there is still blue ocean space in the market

D-borneol is also called d-borneol, also known as natural borneol or natural borneol. D-bornillol is a birotary monoterpene alcohol compound, which mainly appears as colorless crystals under normal conditions. D-borneol is the main active ingredient of borneol. It is volatile, has a refreshing aroma and a pungent and cool taste.

The blood-brain barrier is an important mechanism for the self-protection of the human brain. D-bornillol has the function of regulating the blood-brain barrier, which can promote the penetration of drugs into the blood-brain barrier and improve drug efficacy. It can also protect the blood-brain barrier, reduce oxidative reactions in the brain, inhibit inflammation, and prevent cell apoptosis. It has important application value in the treatment of cerebrovascular and other diseases. D-bornyl also has anti-inflammatory, analgesic, and inhibitory effects on the activity of pathogenic microorganisms. It can effectively relieve acute and chronic pain. It is expected to become an effective ingredient in anti-inflammatory drugs, sterilizing agents and other products, and has a broad market prospect.

In 2020, the edaravone dexbolone drug applied by Nanjing Simcere TECO Pharmaceutical Co., Ltd. received national approval and was officially launched. Edaravone-Dexterobornol Injection is a new drug for the treatment of amyotrophic lateral sclerosis and ALS. It combines the advantages of edaravone in scavenging free radicals and dextrose-bornillol in regulating the blood-brain barrier. Delay the development of ALS and improve patients’ quality of life. In 2022, sales of edaravone dextrose-bornyl injection in hospitals across the country will reach 2.115 billion yuan, an increase of more than double compared to 2021.

According to the “2023-2028 China Dexbobornyl Industry Market In-depth Research and Development Prospects Forecast Report released by the Industrial Research Center , Natural dextrose-bornylol is mainly extracted from natural borneol camphor plants through steam distillation. The extraction purity is high and the clinical efficacy is good. However, the raw materials are scarce and the extraction rate is low, resulting in low production and price of natural dextrose-bornylol. Expensive. Currently, the main product on the Chinese market is synthetic dextrose-bornyl alcohol.

Chemical synthesis of dextrose-bornyl alcohol mainly uses turpentine as the raw material, and is fractionated to obtain α-pinene. Then, it undergoes an esterification reaction with oxalic acid under the action of catalysts such as boric acid liver to generate bornyl ester, and then undergoes alkali saponification to obtain the racemate of bonnol. and isobornyl alcohol, and then separate the product to finally obtain dextral bornol. The chemical synthesis method has the advantages of high product purity and relatively low production costs. However, a large number of strong acidic catalysts are used in the production process, which can easily cause environmental pollution and increase environmental pressure on production companies. At the same time, chemical reactions generate severe heat and production safety is relatively low. Low.

The academic community is now studying the production process of microbial synthesis of d-bobornol, introducing the d-bobornol biosynthetic pathway into microorganisms such as Escherichia coli, and building a microbial cell factory for the production of d-bornyl. Industry analysts said that d-camphenol has extremely high medicinal value. As research on alcohol becomes more in-depth, the market demand for dexbornebornol will continue to grow. At present, there are few companies in my country capable of producing d-bobornol, and the d-bobornol market is in a blue ocean state.