D-p-Hydroxyphenylglycine (D-acid) is mainly used in the pharmaceutical field. Local companies have a competitive advantage in the global market.

D-p-Hydroxyphenylglycine, also known as L-p-hydroxyphenylglycine, referred to as D-HPG, D acid, has a chemical formula of C8H9NO3 and is a lipolysis product. D acid appears as a white or off-white flaky solid, easily soluble in acid and alkali solutions, and slightly soluble in methanol and water. D acid is extremely versatile and can be used as a pharmaceutical intermediate for the production of cephalosporin, amoxicillin and other drugs.

In terms of technology, D acid preparation methods include the glyoxylic acid method and the biological enzyme catalyzed synthesis method. The glyoxylic acid method is the mainstream preparation method of D acid. This method uses active amido, phenol and glyoxylic acid as the main raw materials, and then adds methanol reagent to obtain D acid through separation. This method has low equipment requirements and high technical maturity. It has the advantages of high efficiency and high production efficiency, and is suitable for industrial production.

In terms of raw materials, glyoxylic acid is the main raw material of D acid. It has the characteristics of both acid and aldehyde and is widely used in fine chemicals, organic synthesis and other fields. my country is a major producer of glyoxylic acid, accounting for nearly 50% of the world’s production capacity. Benefiting from mature technology and sufficient supply of raw materials, the development speed of my country’s D acid industry has further accelerated.

According to the “2023-2028 China D-hydroxyphenylglycine (D-acid) industry market in-depth research and development prospect forecast report ” shows that in terms of application fields, D acid is mainly used in the pharmaceutical field, and antibacterial drugs such as cefadroxil and amoxicillin are its end products. Amoxicillin belongs to the penicillin class of antibacterial drugs. It has the characteristics of broad antibacterial spectrum and strong bactericidal effect. It can inhibit Streptococcus, Staphylococcus aureus and Gram bacteria. Its indications include skin infection, genitourinary tract infection, purulent gingivitis, etc. . In recent years, the sales of amoxicillin in my country have continued to grow, driving the market demand for amoxicillin APIs to become increasingly strong. In 2022, my country’s demand for amoxicillin API will reach 40,000 tons. D-acid is an important intermediate for the synthesis of amoxicillin API. The development of downstream industries is accelerating, driving the further expansion of my country’s D-acid market space.

In terms of market competition, my country’s D acid industry is highly concentrated, and local companies have a competitive advantage in the global market. Puluo Pharmaceutical and Xintiandi are the representative companies of D acid in my country, among which Puluo Pharmaceutical is the world’s largest supplier of D acid. Xintiandi focuses on the R&D, production and sales of pharmaceutical intermediates such as D acid, p-toluenesulfonic acid, hydroxydeng salt, methyl ester, etc. Its annual production capacity of D acid reaches nearly 7,000 tons, with a capacity utilization rate of 80%.
         
Industry analysts said that D acid has broad application prospects in the pharmaceutical field. In the future, as market demand is gradually released, its industry development speed will be further speed up. Benefiting from sufficient supply of raw materials and improved technological maturity, my country’s D-acid production capacity has rapidly expanded, output has continued to grow, and it has become one of the world’s major producers. It is expected that in the future, as local companies continue to exert their efforts, my country’s D acid industry will gradually develop in a high-quality direction.