2-The development of chloronicotinic acid industry faces great challenges and the future application space needs to be expanded.

2-Chloronicotinic acid, also known as 2-nicotine acid and 2-chloro-3-pyridinecarboxylic acid, is a chemical substance with the chemical formula C6H4ClNO2. It appears as a gray-white to brown powder. It is insoluble in water and soluble in organic matter such as benzene and toluene. Solvent. 2-Chloronicotinic acid is an important class of fine chemical intermediates and can be widely used in medicine, pesticides, chemical industry and other fields.

There are various production methods for 2-chloronicotinic acid. The commonly used methods are mainly the 3-methylpyridine method, which uses 3-methylpyridine as the raw material and undergoes hydrogen peroxide reaction, ring chlorination reaction, crystallization, distillation, side chain A method to generate 2-chloronicotinic acid through chlorination and other steps; the nicotinic acid method refers to using a mixture of phosphorus oxychloride and phosphorus trichloride as raw materials, by introducing chlorine gas, adding nicotinic acid N-oxide, heating, A method to generate 2-chloronicotinic acid through stirring, cooling and other steps.

According to the “2023-2028 2-chloronicotinic acid industry market in-depth research and investment prospect forecast analysis report” released by the Industrial Research Center It shows that 2-chloronicotinic acid is an important class of pharmaceutical and pesticide intermediates. In the pharmaceutical field, it can be used to prepare AIDS drugs, anti-inflammatory drugs, anti-inflammatory and analgesic drugs, antidepressant drugs, etc. Specific products include nevirapine, mirtazone pyridine, niflufenamic acid, fumicamic acid, pranoprofen, etc.; in the field of pesticides, it can be used to prepare herbicides, insecticides and fungicides. Specific products include boscalid, nicosulfuron, and pyridine. Flufenacet, etc.

From the analysis of the downstream pharmaceutical market, as the update and iteration speed of the anti-AIDS drug market continues to accelerate, the domestic market is already in the stage of replacing the old with the new. As an old anti-HIV drug, nevirapine is used in increasingly smaller amounts, which is not conducive to 2-chloronicotinic acid. Industry development; at the same time, pranoprofen eye drops are also an earlier type of ophthalmic drug that has been developed earlier. Affected by the rapid growth of the new ophthalmic drug market such as aflibercept intraocular injection solution and Conbercept ophthalmic injection, its Sales also declined somewhat. At this stage, due to the accelerated replacement of related drugs, the market space for 2-chloronicotinic acid is gradually shrinking, and industry development is facing greater challenges.

At present, my country is one of the major producers of 2-chloronicotinic acid in the world. The production companies include Cangzhou Lingang Yanuo Chemical, Hubei Xinnovi Chemical, Lianyungang Langyi Chemical, Jiangsu Zhongzheng Biochemical, Xinjianglongzhou Chemical, Gansu Anlong Technology, Ningxia Lantian Agriculture, Jiangsu Jinyu Chemical, Nantong Haisheng Pharmaceutical, Jiangsu Hankuo Biotechnology, Jiangsu Sanpeng Biotechnology, etc.

Industry analysts said that 2-chloronicotinic acid is an important class of fine chemical intermediates. Widely used in medicine and pesticide fields. However, in recent years, the domestic market demand for 2-chloronicotinic acid has declined due to reduced sales of end products, and the market development prospects have been limited. In the future, local companies need to continue to increase research and development efforts related to 2-chloronicotinic acid to promote its application space. Keep expanding.