There are many synthesis methods for citrulline (Cit) and broad application prospects.

Citrulline (Cit), also known as carbamoylornithine, refers to an α-amino acid generated from ornithine and carbamoyl phosphate in the urea cycle, with the chemical formula C6H13N3O3. Citrulline appears as a white crystalline powder with a mild and slightly sweet smell. It is slightly soluble in alcohol, easily soluble in water, and insoluble in ether. Citrulline has antioxidant properties and is widely used in health products, medicines, food additives, cosmetics and other fields.

There are many methods for synthesizing citrulline, mainly including reduction reaction method, synthetic enzyme method, amination reaction method and substrate exchange method. The reduction reaction method refers to using a palladium catalyst to reduce excess hydrogen and oxaloacetate to obtain a finished product. This method has not yet achieved large-scale production. The synthetic enzyme method has the advantages of high purity of finished product, mild reaction conditions, and is suitable for continuous production. It is Mainstream preparation methods of citrulline. In recent years, as the technological maturity of local enterprises has improved, the production and quality of citrulline in my country have further improved.

Citrulline has broad application prospects in health products, medicine, food additives, cosmetics and other fields. In the field of health care products, citrulline has the effects of improving the body’s immunity and relieving fatigue; in the field of medicine, citrulline can be used as a raw material for treating prostatic hypertrophy, prostatitis, prostate cancer and other diseases; in the field of food additives, food High-grade citrulline can be used as an additive in baked goods, dairy products, and condiments; in the field of cosmetics, citrulline has moisturizing and anti-aging effects and can be used to produce facial masks, moisturizers, eye essences and other products.

According to the “2023-2028 China Citrulline (Cit) Industry Market In-depth Research and Development Prospects Forecast Report released by the Industrial Research Center 》shows that citrulline is an amino acid segment product. my country is a major producer and exporter of amino acids, with nearly a hundred production companies. In recent years, driven by positive factors such as strong market demand and the improvement of technological innovation levels of local enterprises, my country’s amino acid production capacity has rapidly expanded, and output has continued to grow, driving the market share of downstream products such as taurine, citrulline, and lysine to continue to increase. .

Attracted by market prospects, the number of companies in my country’s citrulline industry continues to grow, mainly including Jingjing Pharmaceutical Co., Ltd., Shenzhen Maikedian Biomedical Technology Co., Ltd., Hebei Lihua Biotechnology Co., Ltd., and Shandong Pingju Biotechnology Co., Ltd. Technology Co., Ltd., etc. At present, my country’s citrulline market is dominated by small and medium-sized enterprises, with uneven product quality and a lack of large-scale leading enterprises.

Industry analysts said that citrulline has antioxidant, anti-aging, fatigue relief and other effects, and is used in many medicines, health products, etc. The field has broad application prospects. In the future, with the gradual release of downstream demand, the development trend of my country’s citrulline industry will continue to improve. At present, the concentration of my country’s citrulline industry is low, and there are problems such as uneven product quality in the market. Local companies still need to increase investment in research and development to promote the development of my country’s citrulline industry in a high-quality direction.