O-chlorobenzonitrile is widely used and there are not many companies.

​ ​ ​O-chlorobenzonitrile is also called o-chlorobenzonitrile, and its molecular formula is C7H4ClN. O-chlorobenzonitrile is the main raw material for the synthesis of the dye intermediate 2-cyano-4-nitroaniline. It can also be used industrially to synthesize the new anti-malarial drug nitroquine and a variety of anti-inflammatory and bactericidal drugs. It is also used to prepare non-peptide anti-malarial drugs. Angiotensin.

There are many synthetic routes for o-chlorobenzonitrile. Among them, the synthesis of o-chlorobenzonitrile using o-chlorotoluene as raw material is a commonly used synthesis process, and its steps include ammoxidation and nitrosyl chloride cyanation. Using o-chlorotoluene as raw material, it is first chlorinated into o-chlorotrichlorotoluene, and then undergoes a transition metal catalyzed amination reaction to obtain o-chlorobenzonitrile. In the ammoniation reaction stage, zinc oxide or magnesium oxide is often used as a catalyst.

The o-chlorobenzonitrile industry in developed countries such as Europe, the United States, Japan and South Korea developed earlier and has strong competitiveness in the global market. Key production companies include AlzChem, Hoechst, and Nippon Kayaku Co., Ltd. Domestic o-chlorobenzonitrile companies are mainly distributed in Jiangsu Province and Hubei Province, which have relatively developed chemical industries. Due to the influence of competition and environmental protection policies, there are not many companies. Key companies include Dalian Bioao Chemical Co., Ltd. and Lianhua Technology Co., Ltd. Company, Jiangsu Changhai Chemical Co., Ltd., Laohekou Huachen Chemical Co., Ltd., Jiangxi Shilong Industrial Co., Ltd., etc.

Industry analysts said that my country’s o-chlorobenzonitrile companies have not made many innovations in the preparation process. In o-chlorobenzonitrile refining and There are relatively few research results on the invention and improvement of production equipment. On the other hand, my country’s o-chlorobenzonitrile manufacturers have made relatively slow progress in expanding downstream application fields, and the o-chlorobenzonitrile produced by enterprises in the industry is not significantly differentiated.

In addition, o-chlorobenzonitrile is a hazardous chemical, and its production and storage involve certain safety risks. Under the country’s strong safety production supervision, o-chlorobenzene companies are facing increased policy pressure. In 2019, affected by the explosion in Yancheng Xiangshui Chemical Park on March 21, Lianhua Technology and Changhai Chemical suspended the production of o-chlorobenzonitrile, resulting in a serious shortage of domestic product supply and a sharp rise in o-chlorobenzonitrile prices. According to《2022-2026 o-chlorobenzene industry in-depth market The research and investment strategy recommendation report》 shows that the average domestic o-chlorobenzene price in 2021 will exceed 6 Ten thousand yuan/ton.