Comprehensive physical and chemical properties of Tetramethylguanidine (TMG) and its broad prospects for application in many fields

3. Chemical properties

• Basicity: TMG is a strong base, which is stronger than commonly used organic bases such as triethylamine and DBU (1,8-diazabicyclo[5.4.0] One carbon-7-ene).
• Nucleophilicity: TMG has strong nucleophilicity and can react with a variety of electrophiles.
• Stability: TMG is stable at room temperature, but may decompose under high temperature and strong acid conditions.

Applications of tetramethylguanidine in many fields

1. Organic synthesis

• Catalyst: TMG is often used as a catalyst in organic synthesis to promote various reactions, such as esterification, cyclization, hydrogenation, etc.
• Alkaline medium: The strong alkalinity of TMG makes it often used to adjust the pH value of the reaction system in organic synthesis to improve the selectivity and yield of the reaction.

2. Pesticide preparation

• Synergist: TMG can be used as a synergist to enhance the permeability and solubility of pesticides on plant leaves and improve the effective utilization of pesticides.
• Toxicity attenuator: TMG can be used as a toxicity attenuator to reduce the toxicity of pesticides and reduce the impact on non-target organisms.

3. Water pollution purification treatment

• Heavy metal ion removal: TMG can be used as an adsorbent and complexing agent to effectively remove heavy metal ions in water.
• Degradation of organic pollutants: TMG can serve as a catalyst to promote the oxidative degradation of organic pollutants and improve treatment efficiency.
• Removal of nitrogen and phosphorus nutrients: TMG can promote the precipitation and adsorption of nitrogen and phosphorus nutrients and reduce eutrophication of water bodies.

4. Heterogeneous catalytic reaction

• Esterification reaction: TMG acts as a catalyst to promote the reaction of acid and alcohol to generate ester and water.
• Hydrogenation reaction: As a cocatalyst, TMG works synergistically with the metal catalyst to promote the activation and transfer of hydrogen and improve the efficiency of the hydrogenation reaction.
• Cyclization reaction: TMG acts as a catalyst to promote the cyclization reaction of organic molecules to generate cyclic compounds.
• Oxidation reaction: TMG acts as a catalyst to promote the oxidation reaction of organic molecules and generate oxidation products.

5. Pharmaceutical field

• Drug synthesis: TMG is often used as a catalyst and alkaline medium in drug synthesis to promote the synthesis of many drugs.The synthesis of �� bodies.
• Drug preparations: TMG can be used as an excipient in pharmaceutical preparations to improve the solubility and stability of drugs.

6. Materials Science

• Polymer synthesis: TMG can serve as a catalyst to promote polymer synthesis and improve polymer performance.
• Functional materials: TMG can be used as an additive for functional materials to improve the properties of materials, such as conductivity, thermal stability, etc.

Specific cases of tetramethylguanidine application in various fields

1. Organic synthesis

• Case Background: When an organic synthesis company was producing a certain ester product, it found that the traditional catalyst was not effective, affecting production efficiency and product quality.
• Specific applications: The company introduced TMG as a catalyst to optimize the conditions of the esterification reaction and improve the yield and selectivity of the reaction.
• Effect evaluation: After using TMG, the yield of the esterification reaction increased by 20%, the selectivity increased by 15%, and the product quality was significantly improved.

2. Pesticide preparation

• Case Background: When a pesticide company was developing highly efficient and low-toxic organophosphorus pesticides, it discovered that traditional organophosphorus pesticides were ineffective and highly toxic.
• Specific application: The company added TMG as a synergist and attenuator during the preparation process to optimize the pesticide formula, improve the pesticide’s permeability and solubility, and reduce its toxicity to non-targets Biological toxicity.
• Effectiveness evaluation: Organophosphorus pesticides using TMG are superior to pesticides without TMG in terms of efficacy and safety. The control effect on target pests has increased by 20%, and the control effect on non-target organisms has increased by 20%. Toxicity reduced by 30%.

3. Water pollution purification treatment

• Case Background: When a city sewage treatment plant was treating domestic sewage, it was found that traditional methods were not effective, especially the removal rate of organic pollutants and nitrogen and phosphorus nutrients was low.
• Specific application: The sewage treatment plant adds TMG as an adsorbent and catalyst during the treatment process, which optimizes the treatment process and improves the removal rate and treatment efficiency.
• Effectiveness evaluation: After using TMG, the removal rate of organic pollutants in domestic sewage increased by 20%, and the removal rate of nitrogen and phosphorus nutrients increased by 15%.

4. Heterogeneous catalytic reaction

• Case Background: When a pharmaceutical company was producing certain drug intermediates, it was discovered that the traditional hydrogenation catalyst was not effective, which affected production efficiency and product quality.
• Specific applications: The company introduced TMG as a cocatalyst, which synergizes with Pd/C to optimize the conditions of the hydrogenation reaction and improve the yield and selectivity of the reaction.
• Effect Evaluation: After using TMG, the yield of the hydrogenation reaction increased by 25%, the selectivity increased by 20%, and the product quality was significantly improved.

Technical characteristics of tetramethylguanidine in various fields

1. Efficiency

• Catalytic efficiency: TMG exhibits efficient catalytic activity in a variety of reactions, significantly improving the yield and selectivity of the reaction.
• Treatment efficiency: TMG shows high removal capacity and treatment efficiency in water pollution purification treatment.

2. Selectivity

• Reaction selectivity: TMG exhibits high reaction selectivity in organic synthesis and heterogeneous catalytic reactions, reducing the formation of by-products.
• Pollutant selectivity: TMG shows high pollutant selectivity in water pollution purification treatment, reducing the impact on non-target organisms.

3. Environmental friendliness

• Low toxicity: TMG itself has low toxicity and will not cause significant pollution to the environment.
• Renewability: TMG can be regenerated in certain reactions, improving its efficiency and economy.

Future prospects for the application of tetramethylguanidine in many fields

• Development of new catalysts: Further study the synergy between TMG and other catalysts to develop more efficient catalyst systems.
• Multifunctional Material Design: Explore the application of TMG in new functional materials, such as conductive materials, thermally stable materials, etc.
• Environmental Protection: Continue to study the application of TMG in water pollution purification treatment and develop more environmentally friendly and efficient treatment technologies.
• Pharmaceutical Innovation: In-depth research on the application of TMG in drug synthesis and formulation, and the development of new drugs and formulation technologies.

Extended reading:

Addocat 106/TEDA-L33B/DABCO POLYCAT

Dabco 33-S/Microporous catalyst

NT CAT BDMA

NT CAT PC-9

NT CAT ZR-50

4-Acryloylmorpholine

N-Acetylmorpholine

Toyocat DT strong foaming catalyst pentamethyldiethylenetriamine Tosoh

Toyocat DMCH Hard bubble catalyst for tertiary amine Tosoh

TEDA-L33B polyurethane amine catalyst Tosoh