Stearyl alcohol appears as a white flake or granular solid with a fragrance, insoluble in water, and soluble in ethanol, ether, benzene, and chloroform. It can be obtained by hydrolysis of pilot whale oil, hydrogenation of stearic acid under the catalysis of copper chromate, or reduction of ethyl stearate with saturated ethanol. It can also be obtained by controlling the polymerization reaction of ethylene under the action of alkyl aluminum, and then obtain the heptadecene fraction through oxo synthesis.
The determination method of stearyl alcohol is as follows:
Determination by gas chromatography (General Chapter 0521).
Chromatographic conditions and system suitability test: 100% polydimethylsiloxane capillary column as analytical column, flame ionization detector; column temperature 205°C, injection port temperature 250° C, the detector temperature is 250°C; the number of theoretical plates calculated based on the stearyl alcohol peak should not be less than 10,000, and the separation between the stearyl alcohol peak and adjacent chromatographic peaks should comply with regulations.
Determination method: Take 100mg of this product, weigh it accurately, put it in a 100ml measuring bottle, add absolute ethanol to dissolve and dilute to the mark, shake well, accurately measure and inject into the gas chromatograph, and record the chromatogram. ; In addition, accurately weigh an appropriate amount of octadecanol reference substance, add absolute ethanol and dissolve it to make a solution containing 1.0 mg per ml, shake well, operate in the same way, and calculate the content of octadecanol based on the peak area according to the external standard method , that’s it.
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