【1,3-Butanediol supply】Toxicological data of 1,3-butanediol

1,3-Butanediol is a colorless, slightly bitter-sweet viscous liquid. Melting point -77℃. Boiling point 207.5℃. Relative density 1.0043. Viscosity (25℃) 103.9mPa.s. Refractive index 1.4401. Surface tension (25℃) 37.8mN/m. Soluble in water, acetone, methyl-ethyl ketone, ethanol, dibutyl phthalate, castor oil, almost insoluble in aliphatic hydrocarbons, benzene, toluene, carbon tetrachloride, ethanolamines, mineral oil , linseed oil. It dissolves nylon when heated and also partially dissolves shellac and rosin. Because of its high boiling point, it is easily oxidized by air during distillation under normal pressure, so it is better to distill under reduced pressure. Highly hygroscopic.

The toxicological data of 1,3-butanediol are as follows:

1. Skin/eye irritation

Standard Draize test: Rabbit, skin contact: 500mg/24H, severity of reaction: mild.

Standard Draize test: Rabbit, eye contact: 500 mg, severity of reaction: mild.

Standard Draize test: Rabbit, eye contact: 500mg/24H, severity of reaction: mild.

2. Acute toxicity: rat oral LD50: 18610mg/kg; rat subcutaneous LD50: 20mg/kg;

Mouse oral LC50: 12980mg/kg; small Rat intraperitoneal LC50: 10276mg/kg;

Rabbit skin contact LD50: >20mg/kg; Guinea pig oral LD50: 11mg/kg;

3. Reproductive toxicity: rat Oral TDLo: 42360mg/kg (female rats are pregnant for 6-15 days);

4. The toxicity is similar to that of glycerol, which is slightly toxic and has no irritation to human mucous membranes and skin. Animals show symptoms during acute poisoning. Deep anesthesia