Preparation of [4-amino-2-[(1-methanesulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2

Background and overview[1] R547 ([4-Amino-2-[(1-methanesulfonylpiperidin-4-yl)amino]pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl) Methone) is a potent inhibitor of CDKs 1, 2, 4, 7, and 9 and has shown…