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2-[2-[2-Chloro-3-[(1,3-dihydro-1,3,3-trimethyl-2H-indole-2-ylidene)ethylidene]-1-cyclohexane Preparation of alken-1-yl]vinyl]-1,3,3-trimethyl-3H-indole 4-methylbenzenesulfonate_Kain Industrial Additive
Background and overview[1] 2-[2-[2-Chloro-3-[(1,3-dihydro-1,3,3-trimethyl-2H-indole-2-ylidene)ethylene]-1 -Cyclohexen-1-yl]vinyl]-1,3,3-trimethyl-3H-indole 4-methylbenzenesulfonate is a cyanine dye an…
Preparation of 4-(4-methylpiperazine)aniline_Kain Industrial Additive
Background and overview[1] 4-(4-methylpiperazine)aniline can be used as a pharmaceutical intermediate. It can be prepared by reducing p-fluoronitrobenzene with N-methylpiperazine after nucleophilic su…
Preparation of 4-hydroxy-3-methoxy-2-nitrobenzaldehyde_Kain Industrial Additive
Background and overview[1] 4-Hydroxy-3-methoxy-2-nitrobenzaldehyde can be used as a pharmaceutical intermediate, which can be prepared through a three-step reaction using vanillin as the starting mate…
Preparation of 5,6-diphenyl-2-hydroxypyrazine_Kain Industrial Additive
Background and overview[1] 5,6-Diphenyl-2-hydroxypyrazine is a pharmaceutical intermediate that can be prepared in one step from benzoyl and aminoacetamide hydrochloride. There are reports in the lite…
Preparation of (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone_Kain Industrial Additive
Background and overview[1] (3R,4S)-3-Hydroxy-4-phenyl-2-azetidinone, referred to as (-)β-lactam, is a very potential chiral drug intermediate. There are two isomers, namely (3R, 4S) configuration and …
Preparation of 2,4-diphenyl-oxazacyclo-5-acid_Kain Industrial Additive
Background and overview[1] 2,4-Diphenyl-oxazacyclo-5-acid is a pharmaceutical intermediate that can be prepared in two steps from (2R,3S)-3-phenylisoserine and trimethyl orthobenzoate. get. It has bee…
Preparation of (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-tert-butyl ester_Kain Industrial Additive
Background and overview[1] (4S,5R)-2-(4-Methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-tert-butyl ester is a pharmaceutical intermediate, which can be made from ( 2′R,3′S)-phenylisoserine …
Preparation and application of p-toluenesulfonic acid tsoh_Kain Industrial Additive
Background and Overview P-Toluenesulfonic acid (tsoh) was first prepared by Jaworsky in 1865 by sulfonating toluene with sulfuric acid. In 1869, Engelllardt and others discovered that ortho and meta i…
Preparation of 2-bromo-1-chloro-4-trifluoromethoxybenzene_Kain Industrial Additive
Background and overview[1-2] 2-Bromo-1-chloro-4-trifluoromethoxybenzene is a pharmaceutical intermediate, which can be prepared from 2-bromo-4-(trifluoromethoxy)aniline after diazotization and chlorin…
Preparation of 3-amino-4-chlorobenzonitrile_Kain Industrial Additive
Background and overview[1-2] 3-Amino-4-chlorobenzonitrile is a pharmaceutical intermediate. It can be nitrated from p-chlorobenzonitrile to obtain 4-chloro-3-nitrobenzonitrile, and then reduced to obt…
